Development of technology and composition of a transdermal therapeutic system with extraction from milky iris (Iris lactea) herb

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DOI: https://doi.org/10.29296/25419218-2019-01-04
Issue: 
1
Year: 
2019

I.E. Kaukhova, M.V. Aroyan; S.B. Goncharova Saint Petersburg State Chemopharmaceutical University; 14, Prof. Popov St., Saint Petersburg 197376, Russian Federation

Introduction. The design of long-acting drugs, including the development of transdermal therapeutic systems (TTS), is relevant in modern pharmacy. Milky iris (Iris lactea Pall.) has a diverse chemical composition that determines a wide range of its pharmacological effects. The flavonoid glycoside embinin contained in the plant possesses immunomodulatory and antiviral effects. Objective: to create TTS having immunostimulating activity on the basis of extraction from milky iris herb. Material and methods. The object of the investigation was milky iris herb gathered in Transbaikalia. The quality of TTS was assessed according to the standard procedures described in the State Pharmacopoeia of the Russian Federation, XIV edition). Results. The optimal component composition of a transdermal patch matrix was established; its operating process was ascertained; the main indicators of quality of the transdermal patch based on extraction from milky iris herb were determined. Conclusion. The composition and technology of transdermal patch based on extraction from milky iris has been developed for the first time; its standardization carried out.
Keywords: 
milky iris
Iris lactea Pall.
transdermal therapeutic system
embinin
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