DESIGN OF INTRANASAL DOSAGE FORMS: BIOPHARMACEUTICAL ASPECTS

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DOI: https://doi.org/10.29296/25419218-2019-03-02
Issue: 
3
Year: 
2019

N.B. Demina, E.O. Bakhrushina, A.I. Bardakov, I.I. KrasnyukI. M. Sechenov First Moscow State Medical University (Sechenov University), 8, Trubetskaya St., Build. 2, Moscow 119048, Russian Federation

The paper provides an analysis and comparative characteristics of the types of dosage forms of registered intranasal drugs. By using the biopharmaceutical features of the intranasal route of administration, the investigators show the advantages and disadvantages of traditional dosage forms, such as solutions, ointments, lyophilisates, and sprays) and the promising nature of mucoadhesive thermoreversive gels. The current matrix-forming agents (smart polymers and high-molecular-weight compounds) are considered to be promising for designing intranasal gels.
Keywords: 
intranasal gels
mucoadhesive dosage forms
matrix formers
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