ANTICOAGULANT ACTIVITY IN SOME VERBASCUM GENUS PLANTS GROWING IN THE PERM TERRITORY

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DOI: https://doi.org/None
Issue: 
1
Year: 
2015

S.A. Kalinina, PhD; D.V. Kalinin, PhD; D.G. Dianova, PhD; Professor B.Ya. Syropyatov, MD Perm State Pharmaceutical Academy; 2, Polevaya St., Perm 614990

There are published data on the medical use of mulleins (Verbascum) and on their effects on the blood coagulation system. However, there is a paucity of experimental evidence confirming the hemostatic properties of Verbascum genus plants. Aqueous and alcoholic extracts from the vegetative and generative organs of common mullein (Verbascum Thapsus L.) and dense-flowered mullein (Verbascum densiflorum Berfol.) at a concentration of 1 mg/ml have experimentally shown to exert an anticoagulant effect. The extracts of mulleins increase blood clotting time as compared to the control; however, none of them exceeds the anticoagulant activity of heparin. It has been ascertained that the extracts obtained from different plant parts vary in pharmacological activity. It has been also found that the aqueous extracts are more active than the alcoholic ones.
Keywords: 
anticoagulant activity
common mullein (Verbascum Thapsus L.) and dense-flowered mullein (Verbascum densiflorum)
aqueous extract
alcoholic extract
References: 
  1. Kalinina S.A., Molohova E.I., Petrichenko V.M. Razrabotka tehnologii suhogo e`kstrakta travy korovyaka chernogo. Farmaciya, 2012; 5: 38–40.
  2. Kalinina S.A., Petrichenko V.M. Fenol`nye soedineniya suhogo e`kstrakta nadzemnoy chasti Verbascum nigrum (Scrophulariaceae). Rast. resursy, 2012; 42, (2): 237–244.
  3. Kit S.M., Kravchuk G.P. Vliyanie vytyazhek nekotoryh rasteniy Prikarpat`ya na process svertyvaniya krovi. Farmac. zhurn., 1979; 4: 55–58.
  4. Suhinina T.V., Petrichenko V.M., Syropyatov B.Ya., Shestakova T.S. Antikoagulyantnaya aktivnost` rasteniy semeystva norichnikovye. Sb. materialov XIV Rossiyskogo nacional`nogo kongressa «Chelovek i lekarstvo». M., 2007; 882.
  5. Ustinova S.A., Petrichenko V.M., Syropyatov B.Ya. Vliyanie izvlecheniy iz Verbascum nigrum (Scrophulariaceae) na gemostaz. Rast. resursy, 2009; 45, (4): 111–116.
  6. Flora SSSR (Pod red. B.K. Shishkina, E.G. Bobrova). M., L.: Akademiya nauk SSSR. 1955; 22: 705.
  7. Chiryat`ev E.A., Rusakova O.A. Vidy flory Sibiri kak istochnika antikoagulyantov pryamogo deystviya. Rast. resursy, 1994; 30 (4): 21 – 26.
  8. Heywood V.H. Flowering Plants of the World. New York: Oxford University Press. 1993.