ACUTE TOXICITY OF A NEW COMPLEX COORDINATION COMPOUND OF GERMANIUM AND MAGNESIUM WITH CITRIC ACID
DOI: https://doi.org/None
Issue:
1
Year:
2015
The acute toxicity of the new complex coordination compound germacyte composed of germanium, magnesium, and citric acid was investigated. Germacyte has neurotropic, antimicrobial, and antiviral activities. Investigations were conducted on albino ISR mice of both sexes and Wistar rats. The parameters of acute toxicity of the compound were determined for the animals after its intraabdominal and oral administrations. The compound belongs to Class V (virtually nontoxic drugs), when used intraabdominally, and to Class VI (relatively safe), when given orally. Calculating methods were employed to extrapolate the results to human beings. The findings suggest that germacyte is virtually safe for man and promising for further investigation of its pharmacological properties as a potential medication.
Keywords:
complex coordination compounds
magnesium
germanium
citric acid
acute toxicity
References:
- Skal`nyy A.V., Rudakov I.A. Bioe`lementy v medicine. M.: Oniks 21 vek: Mir; 2004: 272.
- Doklinicheskie issledovaniya lekarstvennyh sredstv. Metodicheskie rekomendacii (pod. red. A.V.Stefanova). Kiev: Avіcena, 2002; 567.
- Prozorovskiy V.B. Ispol`zovanie metoda naimen`shih kvadratov dlya probit-analiza krivyh letal`nosti. Farmakologiya i toksikologiya, 1962; 23. (1): 115–120.
- Luk`yanchuk V.D. Metodologicheskie osnovy lekarstvennoy toksikometrii na doklinicheskom e`tape. Vіsnik farmakologії ta farmacії, 2008; 7–8: 20–24.
- Luk`yanchuk V.D., Vysockiy A.A., Kravec D.S. Toksikometricheskie issledovaniya potencial`nogo cerebroprotektora OK-3. Sovremennye problemy toksikologii, 2007; 2: 52–54.
- Gus`kova T.A. Doklinicheskoe toksikologicheskoe izuchenie lekarstvennyh sredstv kak garantiya bezopasnosti provedeniya ih klinicheskih issledovaniy. Toksikologicheskiy vestnik, 2010; 5 (104): 2–6.