THE MEDICAL USE AND STANDARDIZATION OF ANTIOXIDANTS: MEDICINES AND EXCIPIENTS

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DOI: https://doi.org/None
Issue: 
1
Year: 
2015

E.D. Zhuchkova*, O.Yu. Shchepochkina, PhD; O.I. Tereshkina, PhD; E.A. Petrykina, PhD I.M. Sechenov First Moscow State Medical University; 8, Trubetskaya St., Build. 2, Moscow 119991

The paper reviews the literature on the classification of exogenous and endogenous antioxidants according to the principle of the action, pharmacological effect of compounds used as active pharmaceutical substances (APSs) and shows the aspects of safety of the medical use of antioxidants, the specific features of standardization of APSs and their based drugs in compliance with the requirements of the United States, British, European, and Russian Pharmacopoeias. The issues of using antioxidant excipients as stabilizers of different formulations to prevent the oxidation of APSs are considered.
Keywords: 
antioxidants
classification
standardization
practical use
safety
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