DEVELOPMENT OF THE COMPOSITION AND TECHNOLOGY OF INSTANT FURACILIN FORMULATIONS

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DOI: https://doi.org/None
Issue: 
3
Year: 
2015

I.M. Sechenov First Moscow State Medical University; 8, Trubetskaya St., Build. 2, Moscow 11991, Russia

The authors propose the most sophisticated and promising technology to prepare instant granules and tablets containing solid dispersions of furacilin and polyvynylpirrolidone-10000. The quality of the designed dosage forms was assessed; their storage stability was investigated and their shelf-lives were defined. The above technology makes it possible to combine the preparation of solid dispersions, the stirring of components, granulation, and drying in the same apparatus, which allows for continuous production and high efficiency. The developed technology permits not only higher bioavailability of poorly soluble furacilin, but also its significantly less dissolution time.
Keywords: 
furacilin
solid dispersions
polyvynylpirrolidone-10000
solubility
effervescent tablets
granules
bioavailability
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