EXTERNAL FACTORS AND THE PRESERVATION OF ARBUTIN IN THE LEAVES OF LEATHER BERGENIA (BERGENIA CRUSSIFOLIA (L.) FRITSCH) DURING LONG-TERM STORAGE

Download full text PDF
DOI: https://doi.org/None
Issue: 
3
Year: 
2016

D.V. Moiseev (1), PhD; Professor G.P. Yakovlev (2), PhD 1 -Vitebsk State Medical University; 27, Frunze Pr., Vitebsk 210023, Republic of Belarus 2 -Saint Petersburg State Chemopharmaceutical Academy; 14, Prof. Popov St., Saint Petersburg 197376

By using the leaves of leather bergenia (Bergenia crussifolia (L.) Fritsch) as an example, methodological approaches are proposed to predict the shelf-life of plant-based raw materials and to make a decision on a package that ensures the maximum protection of active ingredients from being destroyed. There are data on changes in the content of arbutin in the broken (coarse powder) and unbroken raw materials over a range of temperatures of 20 to 60°C and moisture contents of 9 to 25%. Basic kinetic parameters (rate constant, activation energy, etc.) of occurring reactions of arbutin destruction have been calculated for the raw material stored in the nonhermetic and hermetic packages at different moisture contents. When the raw material is stored in the nonhermetic package at 20°C for 3 years, arbutin concentrations in the unbroken and broken raw materials reduce by 7 and 11%, respectively. Arbutin in the hermetic package is better preserved in the broken raw materials over all storage temperature ranges. The destruction of all the test substances enhances with increases in the storage temperature and moisture contents of raw materials.
Keywords: 
leather bergenia
Bergenia crussifolia (L.) Fritsch
high-performance liquid chromatography
arbutin
storage
package
accelerated tests
References: 
  1. Farmakognoziya. Lekarstvennoe syr`e rastitel`nogo i zhivotnogo proishozhdeniya (pod red. G.P. Yakovleva). SPb.: SpecLit, 2010; 863. [Pharmacognosy. Medicinal raw materials ofplant and animal. (ed. G.P. Jakovlev). SPb.: SpecLit, 2010; 863] (in Russian).
  2. Guideline on quality of herbal medicinal products/ traditional herbal medicinal products EMA/CPMP/QWP/2819/00 Rev. 2. London. September. 2011; 13.
  3. Klick S. Toward a Generic Approach for Stress Testing of Drug Substances and Drug Products. Pharmaceutical Technology, 2005; 2: 48–66.
  4. Moiseev D.V. Novyy metod opredeleniya srokov godnosti lekarstvennogo rastitel`nogo syr`ya (list`ev Rhaponticum Carthamoides) na osnove stress-testa «uskorennoe starenie». Recept, 2012; 2: 47–54. [Moiseev D.V. A new method for determining the shelf life of medicinal vegetative raw materials (leaves of Rhaponticum Carthamoides), on the basis of the stress test «accelerated aging». Recept, 2012; 2: 47–54] (in Russian).
  5. Temerdashev Z.A., Frolova N.A., Cyupko T.G., Chuprynina D.A. Ocenka stabil`nosti fenol`nyh soedineniy i flavonoidov v lekarstvennyh rasteniyah v processe ih hraneniya. Himiya rastitel`nogo syr`ya, 2011; 4: 193–198. [Temerdashev Z.A., Frolova N.A., Cjupko T.G., Chuprynina D.A. Evaluation of stability of phenolic compounds and flavonoids in medicinal plants in the process of storage. Himija rastitel'nogo syr'ja, 2011; 4: 193–198] (in Russian).
  6. Khalid H. Accelerated Stability and Chemical Kinetics of Ethanol Extracts of Fruit of Piper sarmentosum Using High Performance Liquid Chromatography. Iranian Journal of Pharmaceutical Research, 2011; 10 (3): 403–413.
  7. Polenov Yu.V., Egorova E.V. Kinetika himicheskih reakciy. Ivanovo: Ivan. gos. him.-tehnol. un-t, 2010; 68. [Polenov Yu.V., Egorova E.V. Kinetics of chemical reactions. Ivanovo: Ivanovsky State chem.- technolol. university, 2010; 68] (in Russian).