THE ENTEROSORBENT ZEROTOX AND THE INDICATORS OF LIVER FUNCTIONAL AND METABOLIC ACTIVITIES
DOI: https://doi.org/None
Issue:
4
Year:
2016
Background. Enterosorption is part of efferent therapy, the ultimate goal of which is to stop the effect of various toxins and to eliminate them from the body. Objective: to investigation liver functional and metabolic activities during chronic administration of the enterosorbent Zerotox. Material and methods. The powder of a novel enterosorbent obtained from hydrolytic lignin of cottonseed hulls via alkaline refining was examined. The effect of the enterosorbent on the indicators of liver functional and metabolic activities was studied in outbred albino rats (140-160 g) of both sexes. The levels of cytochrome P-450 and cytochrome b5, total and conjugated bilirubin and the activity of microsomal enzymes, alkaline phosphatase, AST, and ALT were investigated in the animals of a control group and in those receiving different doses of the enterosorbent. Results. Changing the indicators of functional and metabolic activities of the cytochrome P-450 system via administration of different doses of the enterosorbent Zerotox caused a statistically insignificant increase in the activities in the experimental groups of animals receiving it at doses of 50 and 100 mg/kg and a reduction in those receiving the enterosorbent at a dose of 500 mg/kg. Conclusion. The enterosorbent Zertox at the examined doses during daily intragastric administration to rats does not affect the activity of the monooxygenase system and the blood indicators characterizing cytolysis and cholestasis.
Keywords:
endogenous intoxication
enterosorption
lignin sorbent
chronic toxicity
cytochrome p-450
cytochrome b5
cytolysis
cholestasis
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